National Institute of Communicable Diseases
Directorate General of Health Services
Ministry of Health and Family Welfare (GOI)
22, Sham Nath Marg, New Delhi-110 054

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ANNUAL REPORT 1997
 
CONTENTS
1.   Introduction
          Organisation Chart
          NICD Faculty/Administration/Staff
          Budget at a Glance (1997)
2.   Objectives and Functions of the Institute
3.   National Health Programmes
          National Surveillance Programme for Communicable Diseases (NSPCD)
          Guinea Worm Eradication Programme (GWEP)
          Yaws Eradication Programme (YEP)
4.   Scientific and Research Activities
       Headquarters
          Division of AIDS & HIV
          Division fo Biochemistry/Biotechnology
          Division of Epidemiology
          Division of Helminthology
          Division of Microbiology
          Division of Medical Entomology/Vector Control
          Division of Training & Malariology
          Division of Zoonosis
       Branches
          Alwar
          Bangalore
          Calicut
          Coonoor
          Jagdalpur
          Patna
          Rajamundry
          Varanasi
5.   Manpower Development/Training Courses, Workshops, Seminars
6.   Outbreak Investigations
7.   Participation in Conferences, Workshops, Seminars and Symposia
8.   WHO/Other International Fellowships
9.   Membership of Expert Committes/Advisory Panel/Honours
10. Important Visitors during the Year
11. Publications/Presentations
Annexures
          Central Library
          Central Animal Facility

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Epidemiology Division

The Division of Epidemiology undertakes the following activities:

§         Organise and co-ordinate training courses in epidemiology to develop trained health manpower.

§         Investigate and recommend remedial measures for the outbreak of diseases of known/ unknown aetiology to the States/Uts of the country.

§         Carry out field research on different aspects of epidemic-prone diseases.

§         Provide support to various National Health Programmes in the form of evaluation of different components/indicators.

§         Provide teaching materials in the form of Modules etc. on various diseases to different health institutions and Guidelines for disease control to State Health Departments.

§         Provide administrative and technical supports to three units at Alwar (Rajasthan), Jagdalpur (Madhya Pradesh) and Coonoor (Tamil Nadu).

§         Monitoring of Yaws Eradication Programme.

§         Provide technical support to Director in Planning and Implementation of National Disease Surveillance Programme (NDSP) and publication of monthly Bulletin “CD Alert”.

§         Statistical guidance to all the Officers of the Division / Institute engaged in various Research activities and Disease control programmes.

Specialised Services and Activities

§         Prepared material for framing reply to Parliament Questions.

§         Surveillance of meningitis in Delhi.

§         Surveillance of Japanese Encephalitis in India.

§         Provided technical support to State Government for outbreak investigations.

§         Imparted training in Field Epidemiology for the state and district levels health officials.

§         Implementation of Yaws Eradication Programme in India.

§         Surveillance of Acute Diarrhoeal Diseases and Cholera in Delhi.

§         Cholera surveillance in Delhi: Zone-wise Compilation and analysis of Cholera cases in Delhi, and preparation of weekly reports on Cholera for perusal of DGHS.

§         Sentinel Surveillance: Compilation of sentinel surveillance data on morbidity and morality status of eleven selected communicable diseases, received monthwise, from 40 identified “Surveillance Centres” in the country.

§         Weekly, district-wise information on morbidity and mortality status of communicable diseases, received from the State of Maharashtra was tabulated and summarised.

Supply of Teaching Materials to other Health Institutions

§         Yaws recognition cards for use in Yaws affected areas.

§         Operational manual on Yaws Eradication Programme (YEP) for field workers.

§         Guidelines for Medical Officers on Yaws Eradication Programme to Health Directorates of Govt. of Orissa, Madhya Pradesh and Andhra Pradesh.

§         Material on control of communicable diseases, occupational health, malaria and Kala Azar to Railways Staff College, Vadodara (Gujarat).

National Disease Surveillance Programme (NDSP)

NDSP has been initiated in five pilot districts, namely; Allepy (Kerala), Alwar (Rajasthan), Gurgaon (Haryana, Kolar (Karnataka) and Mehsana (Gujarat). The progress made during 1997 to implement the programme is as follows:

        i.      Situational analysis of these pilot districts is completed.

       ii.      Training of State and District level ‘Rapid Response Team’ of identified states and districts is completed.

     iii.      Information (such as diagnostic facilities and equipments available) collected from State, District and Referral Laboratories have been analysed to plan for further strengthening of these laboratories. A few observations are as follows:

§         The entire data obtained so far from individual labs on the availability status of various laboratory facilities/ equipments has been computerised into an EXCEL file.

§         Files have been created based on the information available for statewise list of labs that have responded and the percentage of labs presently equipped with each of the selected laboratory facility.

Eight nine laboratories from 14 States have so far furnished information on the facilities existing with them. Some of the findings revealed by the analysis are that microscopic examination of cholera is undertaken by more than 50% of these labs.

Provision for bacteriological examination is very poor, in the region of 20%. Whereas 84% of the labs have Refrigerators available with them, only 20% are equipped with Deep freezers ( - 200C). Microbiology trained medical officers are stationed only in about 50% of the labs.

Research Projects

1.     Aetiology of joundice in urban population – A community based multicentric study, 1997-98

A community based survey was initiated in Bangalore, Calicut, Coonoor and Rajahmundry districts of South India with the objective to ascertain the aetiology of jaundice in urban population. The survey is likely to be completed by the end of the year 1998.

2.     Pre-and extra-material hetero-sexual behaviour of an urban community in Rajasthan, India.

There are about 2.5 million persons infected with HIV in India, heterosexual contact being the most prevalent mode of transmission. Recent trends indicate that HIV infection is spilling over from the so called high risk groups to the general population. Due to vast population size and wide socio-cultural diversity, study of sexual behaviour among the general population of India is neither feasible nor of utility. School teachers, however, can make an important study group as they are role models for general population and specifically for students. The present study was conducted among the teachers of senior secondary schools of a city in Rajasthan state, India, to know the magnitude of pre-and extra-marital hetero-sexual practices and some related characteristics.

The study was conducted between April and September 1997. The study population consisted of all the teachers (totaling 708 with 362 males and 346 females) of all 18 senior secondary schools (up to 12th standard) of the city. Two types of self-reporting questionnaires were used to collect information. Main questionnaires was administered in 13 randomly selected schools and in rest 5 schools, a brief check questionnaire was used for internal validation. Informed consent was obtained from the respondents and confidentiality of their responses maintained.

The study elicited an overall response rate of 73 per cent (males : 72.7%), females: 74.6%). The check questionnaire was representative of 14.6 percent of study population. Pre-material hetero-sexual act (HAS) was present in 34.3 per cent unmarried and 19.6 per cent married males respectively (X2 = 5.8, p < 0.02). The same for unmarried and married females was 11.8 per cent and 1.5 per cent respectively (X2 = 5.3, p < 0.02). The proportion of extra-marital HAS among married males was 15.5 per cent. Ten per cent of married males had both pre-and extra-marital HSA (OR = 15.2). Only one married female had extra-marital HAS. Friends, relations and acquaintances mostly constituted the sexual partners and role of commercial sex workers was negligible. All the values obtained from check questionnaire, except for pre-marital HSA in females, were consistently higher.

The present study revealed that hetero-sexual act, with person other than the legal spouse, is very much prevalent among this educated middle class urban professionals, commercial sex workers being the least preferred partners. Increase in pre-marital HSA among younger (unmarried) generation has also been observed. This situation is conducive for the spread of HIV infection among general population and may adversely influence the sexual attitudes of students. A response rate of 73 per cent, with equal proportions of males and females, is sufficient to represent the study population. Some degree of under-reporting, particularly in the females was possible. The study results suggest that, while intensifying the health education of school students on HIV /AIDS, serious considerations about the sexual behaviour of their teachers teachers are needed. Since authors are unaware of any such study in South East Asia, more research activities willenrich our knowledge in this regard.

3.     Record analysis of cases of poliomyelitis reported in Kalawati Saran Children Hospital, Delhi for the years 1993-96

In India, National immunization programme (EPI) has been in operation since 1978. Though, trend of polio cases has shown decline, it is still a public health problem. A retrospective data analysis was carried out by the participants of the National FETP course with the objective to study the line list of polio cases.

Kalawati Saran Children’s Hospital (KSCH), Delhi is a ‘Sentinel Surveillance Centre’ for many communicable diseases, including poliomyelitis, and accounts for about 80% of the reported poliomyelitis cases of Delhi. The line-list of polio cases during the period Jan. 1993 to October 1996 was obtained from KSCH. One thousand and ninety seven (1097) cases of poliomyelitis were analysed. 38% of total cases were from Delhi and the rest were from the adjoining States. About 30% of Delhi cases were from Shahdara Zones (11 & 12). These Zones are situated at the bank of Yamuna river.

Maintaining the line list of polio cases is important tool for the programme manager of Delhi. 98.8% of the total cases were under the age of 5 years. Out of 1097, 41.3% were infants. The male to female ratio was 1.5:1. 84.2% of cases had lower limb involvement. Trauma within four weeks of the onset of the paralysis has been shown to be a highly significant risk factors for paralytic poliomyelitis (p<0.001). As per the records, 26% of cases were fully immunised with 3 doses of OPV. It is seen that unimmunised children are at a significantly greater risk for developing paralytic poliomyelitis than the immunised children (p<0.01) (A child having less than three doses of OPV was considered as unimmunised regardless of age).

The time lag between onset of illness and collection of stools for virus isolation was also analysed. Of the 208 stool samples, 54.8% was collected during the first week. The highest percentage of polio virus isolation was in this period, which was 66.7%.

This is explained by the intermittent excretion of the poliovirus from the patient, which is maximal in the first week, gradually declining thereafter. Most of this data is with regard to a single collection of stool sample.

4.     Epidemiological analysis of Weekly reports of epidemic prone diseases, Maharashtra for the years 1995-96

Epidemiological surveillance of diseases is an important component of health information system. An efficient health information system is important in planning epidemiological services and evolve epidemiological strategies accessible to personnel of all levels of health hierarchy. NICD is regularly collecting weekly reports on morbidity and mortality of selected 11 epidemic – prone communicable diseases from 30 districts of Maharashtra State. Record analysis of these weekly reports for the period 1995-96 was carried out by the participants of the National FETP course with the objective to study the trend and seasonality pattern of diseases in Maharashtra. 2,06,119 and 2,99,914 cases were recorded for 11 communicable diseases during the years 1995 and 1996, respectively. The number of cases increased by 45.5%. About 99% of cases were of 7 diseases, viz; Acute gastroenteritis, diarrhoea, dysentery, influenza, measles, jaundice and typhoid, the remaining four (cholera, Polio, Encephalitis & diphtheria) accounted for 1%. For comparability between the diseases, further analysis was carried out by converting the data into ‘Index’ form. The index was the highest for the diarrhoea and lowest for measles and typhoid. Data shows the seasonality of diarrhoea, gastroenteritis and dysentery during the months June to September. Since it was a retrospective analysis based on weekly reports, months June to September. Since it was a retrospective analysis based on weekly reports, information like age, address, date of onset, laboratory information could not be obtained.

5.     Epidemiological analysis of Cholera cases reported from different zones of Delhi during 1994-96

To study the epidemiology of cholera reported to Infectious Diseases Hospital, Delhi during the years 1994-96 was carried out by the participants of National FETP course 2023, 1818 and 887 cases were reported respectively during the years 1994, 1995 and 1996. All the Municipal Zones were affected Civil Line Zone (No. 5) and Shahdara Zones (No. 11 & 12) are the worst affected during these years. Cases start occurring during the months May to September with peak in July – August. All the age groups were affected and more than one-third of cases were under the age of five.

6.     Knowledge and practices of urban mothers regarding case management of diarrhoea and acute respiratory infections at household level in Varanasi

A combined survey on diarrhoeal diseases and Acute Respiratory Infections (ARI) was conducted by nine participants of Field Epidemiology Training Programme in the urban areas of Varanasi District (U.P.) having a population of 14.47 lakhs. 30 clusters were surveyed during 22-27 December 1997 with the following objectives:

        i.      To assess the knowledge and practices of mothers of under fives in respect of diarrhoeal diseases regarding a) the use of Oral Rehydration Salt (ORS), b) use of Home available Fluids (HAF), c) feeling practices including breast feeding, d) the knowledge regarding the recognition of early symptoms of dehydration and e) knowledge and practices of referral.

       ii.      To assess the knowledge and practices of motors of mothers of underfives in respect of management of ARI regarding, b) identification of early symptoms of pneumonia and c) referral outside home.

     iii.      To evaluate the coverage of OPV during the first round of pulse polio Information related to ORT, ARI and Pulse-Polio programmes was collected simultaneously, either from mother or caretaker of underfive children on modified and pre-tested questionnaire.

Out of 1386 under 5 yrs children surveyed, 225 were found to be suffering from diarrhoeal diseases within the last two weeks giving 2.3 episodes / child / year (with seasonal correction factor). Out of 225 diarrhoel cases mothers of 220 children could be interviewed regarding  the practices adopted for case management during the diarrhoeal episode. 76.6% continued to breasfeed their infants and 87.6% continued to feed their children either solid or semisolid food. ORS use rate was found the be 20.5% and the correct preparation of ORS (i.e. dissolution of pkt of ORS in 1 litre of potable water) was fond to be only 6.7%. Use of home available fluid (HAF) like sugar salt solution (sss), rice water, dal ka pani, mild tea was 56.5% by the mothers. 76.8% mothers had the knowledge regarding the early symptoms of dehydration. However 70 (31.8%) children developed symptoms of dehydration during diarrhoeal episodes. Out of 70, 9 mothers (12.8%) attended government health facilities for management of dehydration and 54(77.1%) mothers contacted private doctors. On inquiry about not contacting govt. doctors for management of dehydration, the reasons given were (i) place inconvenient (42.9%), (ii) medicine not available (27%), (iii) not attended properly (28%) and (iv) no faith in govt. doctors. Out of the 1386 under 5 children surveyed 377 (27.2%) cases of ARI within the last two weeks were found giving 10.1 episodes/child/year (with seasonal correction factor). Out of the 377 cases of ARI, mothers of 298 cases could be interviewed regarding the ARI case management at household level. 88.1% of the mothers continued breast feeding their infants, 96.1% of mothers continued to feed their children either solid or semi-solid food. 68% of the mothers had the knowledge of danger symptoms associated with ARI. 67 (25.9%) of children developed the danger symptoms of pneumonia. Out of 67 only 8 (11.9%)  mothers contacted the government health facilities and 56 (83.6%) contacted private doctors. On being enquired about the reasons for not contacting the government health facilities for the management of pneumonia the reasons given were (i) medicine not available (38.9%), (ii) not attended properly (28.9%) and (iii) no faith in government doctors (28.8%).

In order to evaluate the first round coverage of OPV among under 5 children, a survey was conducted simultaneously. 518 children under 5 were contacted. 469 (90.5%) gave history of having received OPV during the first round of pulse polio in urban areas of Varanasi District (UY.P.). Reasons given by the 49 (4.5%) mothers for not giving OPV to their children on Dec. 7, 1997 were as follows – forgotten (24.4%), day was not known (20.4%), child was sick (14.3%), and 2 mothers did not give any reason.

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